Browse All Picayune MS Between $400K - $500K Properties for Sale

PRIME COMMERCIAL OPPORTUNITY IN THE HEART OF TOWN! Endless possibilities await with this spacious 7,200-square-foot commercial building situated on THREE city lots! Featuring a NEW ROOF and HVAC system, this property was most recently operating as a daycare with 10 rooms, offering a versatile layout ready for its next chapter. Interior features include multiple spacious rooms, reception area, kitchen space, and plenty of room for offices or specialized services. Outside, you'll find ample paved parking, covered areas, and a large fenced outdoor space. With excellent road frontage and a convenient central location, this property offers outstanding visibility and accessibility. Whether you're envisioning a medical office, therapy clinic, assisted living facility, educational center, or another business venture, the possibilities are tremendous! All potential uses are subject to applicable zoning, licensing, and approval requirements. Don't miss this incredible investment opportunity

611 E Canal Street, Picayune

Listing courtesy of The Smith Team Realty Group DBA The Smith Group Realty.

$419,000

3 Beds ⋅ 3 Baths ⋅ 4164209 MLS

This beautiful 3 bed 2bath home with an extra room with built in bunks offers the perfect combination of comfort, convenience, and space for entertaining—all less than 2 miles from I-59, making it an excellent choice for commuters. Inside, you'll find an inviting open living area, beautiful crown molding, custom cabinetry, granite countertops, stainless appliances, and plenty of storage. The spacious primary suite features a tray ceiling and room to unwind. Step outside and discover a backyard made for entertaining! Enjoy the in-ground pool, expansive patio, and impressive covered outdoor living area, perfect for cookouts, game days, and gatherings with family and friends. The fenced backyard also provides plenty of additional lawn space and storage. Located in desirable Heritage Oaks Subdivision with quick access to shopping, dining, and I-59. This one is ready for you to make it home!

512 Pemberton Place, Picayune

Listing courtesy of The Smith Team Realty Group DBA The Smith Group Realty.

$439,500

3 Beds ⋅ 3 Baths ⋅ 4163815 MLS

Welcome to The Woods Subdivision! This spacious 3BR/2.5BA home offers 2,871 heated/cooled sq ft and 3,477 total sq ft. Features include 10 & 12 ft ceilings, custom-built cabinetry, gas fireplace, craft room and exceptional storage with 7 additional closets beyond the bedroom closets. The primary suite features his & hers vanities, jetted tub, separate shower, his & hers closets and dressing area. Two A/C units and two water heaters add convenience. The 2-car garage includes a storage room and gardening room. A spacious, well-designed home with storage galore! Plat & Survey should be relied on for property boundary lines. MLS pictures are not deemed reliable for identification of property and should not be relied on by Buyer

6008 Woods Road, Picayune

Listing courtesy of RE/MAX Premier Group.

$415,000

3 Beds ⋅ 2 Baths ⋅ 4162778 MLS

STUNNING ALL-BRICK HOME IN HERITAGE OAKS! Better than new, this beautifully upgraded 2023-built home sits on an impressive nearly half-acre corner lot in one of Picayune's most sought-after neighborhoods. From the moment you step inside, the wide-open floor plan, luxury vinyl plank flooring, recessed lighting, and inviting electric fireplace create an incredible living space. The show-stopping kitchen features crisp white cabinetry, stainless steel appliances, a massive island with waterfall quartz countertops, custom backsplash, pot filler, and built-in wine cooler, perfect for both everyday living and entertaining. The adjacent dining area features charming brick flooring and views of the spacious backyard. Bonus office in front of the house gives you tons of versatility. The private primary suite offers a spa-like retreat with a freestanding soaking tub, oversized walk-in shower, and enormous walk-in closet. A spacious laundry room with sink and abundant cabinetry adds convenience and storage. Step outside to the oversized covered rear patio, ideal for entertaining, grilling, or relaxing while still leaving plenty of room for kids, pets, and outdoor activities. The side-load two-car garage adds to the home's impressive curb appeal, while the huge detached garage/workshop provides endless possibilities for a workshop, storage, hobbies, recreational equipment, or additional workspace. With quality construction, extensive upgrades, an exceptional lot, and abundant storage, this is a rare opportunity to own a truly move-in-ready home in Heritage Oaks!

617 Deason Drive, Picayune

Listing courtesy of 1 Percent Lists Realty Professionals, LLC.

$436,000

4 Beds ⋅ 4 Baths ⋅ 4162568 MLS

"Listed below appraisal." Beautiful Home in Heritage Oaks Subd. This home has so many upgrades! Ceilings are 10' and kitchen counter tops are quartz. All appliances are stainless with a 6-burner propane range/oven. The island has power and the countertop is custom cut wood. There is a formal dining rm. and lge. open living rm. area. The m. b/rm. features a walk-in shower and seperate tub w/ a very lge. walk-in closet. There is ample storage in the laundry area and garage. The backyard features a lge. covered patio. There is a rainbird system and ground lights w/timer. The landscape is beautiful and is low maintenance with a vinyl fenced backyard for your privacy.

139 Jefferson Davis Parkway, Picayune

Listing courtesy of Ford Realty, Inc..

$425,000

3 Beds ⋅ 2 Baths ⋅ 4161225 MLS

Beautiful home located on the Main Lake! This home is situated on 2 ea. lots that have been combined. There is a formal dining rm., sunroom w/wet bar and office nook off the kitchen. The fireplace has propane log insert, and the kitchen features a propane 6 burner cooktop. All appliances are stainless. High ceilings are throughout and bedrooms are spacious. The m. bath has a jetted tub, separate walk-in shower, double vanity and 2 ea. walk in closets. The garage is oversized w/ separate access door for mower. The back porch has an open view of the lake. There is a small workshop with power. There is also a well that is approximately 1000 ft. deep used to water the lawn and a new roof.

1006 Woods Road, Picayune

Listing courtesy of Ford Realty, Inc..

$400,000

4160228 MLS

2025 Metal Commercial Building | Food Processing, Retail & Office Opportunity Prime commercial opportunity in Picayune, MS! This 2025 metal commercial building features a brand-new interior built-out completed in 2026, and the owner has never occupied the property. Everything is new and thoughtfully designed for a variety of business uses. The interior features 10' drop ceilings, LED lighting, sealed floors and baseboards, two large rooms finished with FRP board on the walls and ceilings for food-processing, applications, two large sinks, a three-compartment sink, dedicated hand-washing sink, and two A/C systems. Spray-in foam insulation provides an exceptional thermal envelope, creating an interior environment designed to retain temperature like an ice chest. Additional features include a welcoming lobby, conference room, large parking lot, and three steel-structure overhangs providing valuable covered exterior space. The flexible layout offers excellent potential for food processing, office space, retail, or other commercial uses. Conveniently positioned just off Hwy 11, the property offers easy access, consistent traffic flow, and excellent visibility---an ideal fit for a business seeking accessibility and local exposure. Turnkey, all-new construction ready for its next business venture!

106 Haydon Oaks Drive, Picayune

Listing courtesy of Coldwell Banker Alfonso Realty-BSL.

$425,000

2 Beds ⋅ 1 Baths ⋅ 4159717 MLS

8 ACRES • LAKE • BARNDOMINIUM • PRIVACY! Looking for a property with room to spread out, work, play, garden, & enjoy the outdoors? This one checks a LOT of boxes! *8 beautiful acres with a lake *2,400 sq. ft. Barndominium *2 Bedrooms | 1 Bathroom *Heated & cooled workshop area *2 Roll-up doors *Dedicated garden area *Private well & septic *Partially cleared with plenty of privacy Inside, you'll find a comfortable living and dining combination, while the back of the Barndominium offers a spacious heated & cooled workshop—perfect for projects, hobbies, equipment, home business, or additional workspace. Outside is where this property really shines! With 8 acres, your own lake, garden space, storage, & plenty of privacy, there's room to create the country lifestyle you've been dreaming about. Whether you're looking for a full-time home, weekend retreat, hobby property, or a place with plenty of workspace, this property offers SO much potential!

90 Boaz Place, Picayune

Listing courtesy of The Smith Team Realty Group DBA The Smith Group Realty.

$417,000

4 Beds ⋅ 3 Baths ⋅ 4155440 MLS

Beautiful Home located off the main entrance drive. This home has several upgrades including appliances and quartz countertops. The fireplace is an electric insert wall mount with remote. Ceilings are 10 ft. with crown. The floor plan is an open split floor plan with dining area.

509 Pemberton Place, Picayune

Listing courtesy of Ford Realty, Inc..

$424,000

4 Beds ⋅ 3 Baths ⋅ 4149271 MLS

***$5,000 Closing Allowance*** Welcome to your private retreat on 25 acres of open land and wooded serenity. This generous 4 bedroom, 3 bathroom home offers room to spread out, entertain, and enjoy the quiet of country living without sacrificing comfort. The main floor centers around a spacious primary suite that features a double vanity, walk in shower, and soaking tub. Two additional bedrooms and a full bath provide convenience and flexibility. A formal dining room sets the stage for gatherings, while the sunroom brings the outdoors in with warm natural light. The bonus room adds even more versatility for work, play, or relaxation. Upstairs, a private bedroom and full bath create the perfect guest suite or quiet retreat. With its acreage, layout, and inviting living spaces, this home is ideal for anyone seeking comfort, privacy, and room to grow.

825 Liberty Road, Picayune

Listing courtesy of 1 Percent Lists Realty Professionals, LLC.

$425,000

4 Beds ⋅ 5 Baths ⋅ 4124189 MLS

***BACK ON THE MARKET- BELOW APPRAISED VALUE*** Private Cypress Home on 2.51 Acres! Now offered at a new, improved price—don't miss this opportunity to own Parcel #2 on the attached survey, featuring a one-of-a-kind 4-bedroom, 5-bath cypress home situated on 2.51 partially wooded acres. Enjoy the perfect blend of privacy, space, and convenience, all just 15 minutes from the interstate. Step inside to soaring ceilings, abundant natural light, and an updated kitchen with new appliances. Recent improvements—including a brand-new freight elevator, new downstairs A/C unit, and a durable metal roof—provide long-term value and peace of mind. Relax on the spacious Acadian-style front porch or entertain family and friends beneath the expansive covered area below the home, perfect for crawfish boils, barbecues, and outdoor gatherings. The surrounding property offers plenty of room for recreation, gardening, or simply enjoying the peaceful country setting. No Restrictions - Endless Possibilities Bring your animals, add additional buildings, or create the country lifestyle you've always wanted without restrictive covenants. With its new lower price, valuable updates, and added incentives, this property delivers outstanding value. Don't miss your opportunity to own this unique country retreat—schedule your private showing today!

7711 Cuevas Town Road, Picayune

Listing courtesy of Allied Realty Coastal Homes.

S Leetown And Highway 43 Highway, Picayune

$405,000

4067215 MLS

In the Country Heavily 45acres wooded property that has potential , with over 3800 feet on highway 43 and 2700 feet on Leetown road.

S Leetown And Highway 43 Highway, Picayune

Listing courtesy of Regional Realty Group, LLC.

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Copyright 2026 Mississippi Gulf Coast Multiple Listing Service, Inc. Buyer and/or Buyer's Agent should verify data and evaluate source. This information is furnished by the Mississippi Gulf Coast Multiple Listing Service, Inc. This data is copyrighted and may not be transmitted, retransmitted, copied, framed, repurposed, or altered in any way for any other site, individual and/or purpose without the express written permission of the Mississippi Gulf Coast Multiple Listing Service, Inc. All properties are subject to prior sale, change or withdrawal. Neither the MLS nor the Listing Broker will be held responsible for any typographical errors, misinformation and misprints and shall be held totally harmless. Data displayed is a portion of, and not a complete listing of all listing information published in the Mississippi Gulf Coast Multiple Listing Service, Inc.

Between $400K - $500K Picayune Real Estate

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Browse All Picayune MS Between $400K - $500K Properties for Sale

Between $400K - $500K Picayune Real Estate

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