View All Latest Picayune 2250+ Sq. Ft. Properties for Sale

Welcome to a truly exceptional custom-built estate where luxury, functionality, and space come together on 6 beautifully landscaped acres. Offering 5 bedrooms, 4.5 bathrooms, an additional private office and secondary upstairs living room, a two-car garage, and just under 4,500 square feet of heated and cooled living space, this meticulously maintained home was thoughtfully designed for comfortable everyday living and unforgettable entertaining. The heart of the home is a stunning chef's kitchen featuring abundant workspace, custom cabinetry, and generous storage, opening to spacious living areas perfect for gathering with family and friends. Upstairs, you'll find an additional living room, providing the ideal space for a media room, game room, or kids' retreat. With generously sized bedrooms and multiple living spaces, this home offers room for everyone. Step outside to your own private resort. The gunite in-ground pool is complemented by a fully equipped pool house featuring a bathroom, shower, and a covered outdoor kitchen—perfect for entertaining year-round. Both the pool house and the shop include covered lean-to areas, providing excellent storage for lawn equipment, ATVs, or other outdoor gear. The impressive shop is a dream come true, offering a heated and cooled gym, a large workshop, and an oversized open bay with ample room for boats, vehicles, RVs, or other large equipment. Whether you're a hobbyist, business owner, or simply need exceptional storage, this space is ready to accommodate it all. The outdoor amenities continue with a disc golf course, a basketball goal, pickleball court, and beautifully maintained grounds that provide endless opportunities for recreation and relaxation. The manicured landscaping and mature surroundings create a peaceful setting while still offering all the conveniences of modern living. If you've been searching for a move-in-ready estate that offers luxury, privacy, and unmatched versatility, 11185 Bud Lee Road is a rare opportunity you won't want to miss. With a custom-built home, two-car garage, incredible shop, resort-style pool, and six picturesque acres, this one-of-a-kind property truly has it all.

11185 Bud Lee, Picayune

Listing courtesy of eAgent Gulf Coast.

$749,999

4156149 MLS

9.60± Acres of Prime Commercial Development Opportunity! An exceptional opportunity to own approximately 9.60 acres of high-visibility commercial property in one of the fastest-growing areas around. With Interstate 59 less than one minute away and State Highway 11 just moments from the property, this location offers outstanding accessibility and exposure. Surrounded by established businesses and essential services—including a hospital, police department, grocery store, gas stations, restaurants, and other commercial development—this property is perfectly positioned for future growth. Whether you're envisioning: Medical or professional office space Retail or shopping center Restaurants or fast-food franchises Hotel or hospitality Mixed-use development Business park or investment opportunity ...the possibilities are virtually endless. The property consists of five contiguous parcels being sold together for a total of approximately 9.60 acres (per tax records). Survey available for review. If you're looking for a premier commercial site with unbeatable access, visibility, and surrounding amenities, this is one you won't want to miss. Listing agent is related to the seller.

00 Highland Parkway, Picayune

Listing courtesy of Epique.

$165,000

3 Beds ⋅ 2 Baths ⋅ 4156081 MLS

Versatile commercial property situated on a prominent corner lot in Picayune. Offering approximately 1,413 square feet, the building features three bedrooms or private offices, two bathrooms, a kitchen, laundry room, dining room, living room, and an enclosed sunroom with heating and air conditioning. Previously used as a child care/nursery facility, the layout offers potential for office, professional, educational, or other permitted commercial uses. This property is in need of TLC and is being sold strictly "As Is," with the seller making no repairs. Bring your vision and transform this space into your next business location or investment opportunity.

815 Williams Avenue, Picayune

Listing courtesy of Realty One Group Immobilia.

$417,000

4 Beds ⋅ 3 Baths ⋅ 4155440 MLS

Beautiful Home located off the main entrance drive. This home has several upgrades including appliances and quartz countertops. The fireplace is an electric insert wall mount with remote. Ceilings are 10 ft. with crown. The floor plan is an open split floor plan with dining area.

509 Pemberton Place, Picayune

Listing courtesy of Ford Realty, Inc..

$380,000

4 Beds ⋅ 3 Baths ⋅ 4153734 MLS

Are you looking for a home full of charm on unrestricted acreage? Welcome to 94 D and N Road in Picayune, Mississippi. Tucked away from the main road on 5 unrestricted acres, this property offers the privacy, flexibility, and freedom that so many buyers are searching for. Whether you envision a large garden, chickens, a few animals, outdoor hobbies, or simply room to spread out, this property gives you the opportunity to create the lifestyle you want. The home itself is equally impressive, offering 3,089 square feet of living space, plus 570 square feet of covered porches and an additional 507 square feet of uncovered decks. There is plenty of room to enjoy both indoor and outdoor living, entertain guests, or simply relax and take in the peaceful surroundings. Inside, you'll find vintage charm throughout, including real solid wood doors, trim, and a stunning wood staircase that showcase a level of craftsmanship rarely found in today's construction. The spacious floor plan features 4 bedrooms and 3 bathrooms, providing flexibility for entertaining, remote work, hobbies, and everyday living. While the setting feels private and secluded, modern conveniences are closer than you might think. Despite being tucked away down a quiet country road, this home has access to high-speed internet and is located just 4 miles from grocery stores, restaurants, and everyday amenities in the heart of Picayune. Properties that combine acreage, character, square footage, and unrestricted land are becoming increasingly difficult to find. Picayune is a popular spot for locals and commuters alike thanks to its convenient access to NASA's Stennis Space Center, New Orleans, and the Mississippi Gulf Coast. Located less than 5 miles from I-59 Exit 6, this property offers the best of both worlds: peaceful country living with an easy commute. Move-in ready and available for showings today.

94 D And N Road, Picayune

Listing courtesy of Good Neighbor Real Estate, LLC.

$405,000

3 Beds ⋅ 3 Baths ⋅ 4152534 MLS

On nearly 20 acres, this beautifully remodeled 3 bed 3 bath home has two primary suites, a handicap accessible layout, new HVAC, two A/C units, and endless possibilities for country living. Move in ready, privacy, land, gardening, farming, with already planted peach, satsumas, japanese plum, and pecan trees! Exterior 2x6 and interior 2x4 walls! This property has it all with NO RESTRICTIONS.

8360 Cuevas Town Road, Picayune

Listing courtesy of Real Broker, LLC..

$309,000

3 Beds ⋅ 3 Baths ⋅ 4152174 MLS

Country Living at Its Finest on 2.1 Acres! Escape to your own private retreat with this spacious 3-bedroom, 2.5-bath home offering plenty of room to spread out and enjoy the peaceful surroundings. Nestled on a beautiful 2.1-acre parcel, this property combines comfort, nature, and endless possibilities. The home features generous living spaces, a large covered carport, and a backyard designed for relaxation and recreation. Cool off in the above-ground swimming pool, unwind in the hot tub, or transform the existing concrete pad into your very own pickleball court, basketball court, or outdoor entertaining area. Nature lovers will appreciate the scenic path leading to the river, where you can sit back, listen to the soothing sounds of the water, enjoy your morning coffee, or spend an afternoon reading in a tranquil setting. The property is truly a nature lover's paradise, offering privacy, beauty, and abundant wildlife. An added bonus is the separate one-bedroom efficiency cottage, perfect for guests, extended family, a home office, or potential rental income. Three storage sheds provide plenty of space for tools, equipment, and hobbies. This one-of-a-kind property offers the perfect blend of country charm, outdoor living, and versatile amenities. If you've been dreaming of a peaceful retreat with room to roam, this is the place you've been waiting for!

557 Walkiah Bluff Road, Picayune

Listing courtesy of ERA Top Agent Realty.

$335,000

3 Beds ⋅ 2 Baths ⋅ 4149281 MLS

HOME HAS NEVER FLOODED! Peaceful country living on 16.6 wooded acres! This elevated home offers peaceful views from the spacious covered back porch. A sandy-bottom creek runs through the property, creating a beautiful setting for outdoor recreation and wildlife. This home features covered parking and a lift for added accessibility. A large utility shed with a lean-to on each side provides additional space for parking, equipment, hobbies, or outdoor gear. Inside you will find spacious bedrooms and a large kitchen with a walk-in pantry. This property offers a rare combination of acreage, seclusion, and functionality. Call today to schedule your viewing!

24433 Catahoula Lane, Picayune

Listing courtesy of All Phase Real Estate.

$439,000

4 Beds ⋅ 3 Baths ⋅ 4149271 MLS

Welcome to your private retreat on 25 acres of open land and wooded serenity. This generous 4 bedroom, 3 bathroom home offers room to spread out, entertain, and enjoy the quiet of country living without sacrificing comfort. The main floor centers around a spacious primary suite that features a double vanity, walk in shower, and soaking tub. Two additional bedrooms and a full bath provide convenience and flexibility. A formal dining room sets the stage for gatherings, while the sunroom brings the outdoors in with warm natural light. The bonus room adds even more versatility for work, play, or relaxation. Upstairs, a private bedroom and full bath create the perfect guest suite or quiet retreat. With its acreage, layout, and inviting living spaces, this home is ideal for anyone seeking comfort, privacy, and room to grow.

825 Liberty Road, Picayune

Listing courtesy of 1 Percent Lists Realty Professionals, LLC.

$349,990

4 Beds ⋅ 4 Baths ⋅ 4148553 MLS

Step into timeless charm with this beautiful home, nestled in the well maintained Westside neighborhood. Rich in character and full of potential, this charming home blends vintage appeal with spacious living. Inside, you'll find two master suites downstairs and generously sized bedrooms upstairs featuring classic built-ins that add both charm and functionality. The lovely and spacious kitchen offers plenty of room to gather, cook, and entertain, complemented by beautiful butcher block countertops and a large walk-in pantry! This home's cozy atmosphere makes it easy to envision everyday living filled with comfort and style., and is truly a special opportunity. Come experience the charm, space, and potential of this Westside gem—ready to welcome its next owners!

611 Glenwood Street, Picayune

Listing courtesy of The Cuccio Group, LLC.

$870,000

7 Beds ⋅ 7 Baths ⋅ 4144405 MLS

Gorgeous custom Tudor home with plenty of space for hosting parties and large families. Property has many fruit trees, inground pool, work shop, and 5-acre pond, 2 gazebos and picnic area. Brand new updated master bath awaits with large master suite with fireplace. Cooking dinners made easy with a double island kitchen, a butler's pantry that opens to the formal dining room and additional flex space with a wet bar. Plenty of space in a 30x40 workshop to hold equipment and work on projects with the kids.

2655 S Highway 43, Picayune

Listing courtesy of Templet Realty, LLC.

$575,000

6 Beds ⋅ 5 Baths ⋅ 4143984 MLS

This custom built stately 6 bedroom home on a semi-private country road offers space for everyone to do their own thing and room to gather together. Features include a billiards room complete with pool table and a separate entrance; a stunning stone fireplace in the great room; dreamy huge kitchen with beautiful glass front cabinets; kitchen deck overlooking the sandy beaches on the Hobolochitto Creek; formal dining room; music/living room; two bedroom ensuites on Level I; Primary Suite with Sitting room; 2 New HVAC systems; attached garage; mud room/utility entrance; and serene landscaping with a wrought iron fountain. All of this in a quiet country setting less than 2 miles to I-59; one hour to downtown New Orleans and within an hour's drive to 2 International airports.

63 Fritz Whitfield Road, Picayune

Listing courtesy of Compass.

$479,900

4 Beds ⋅ 3 Baths ⋅ 4142652 MLS

PRICE REDUCTION! If you're serious about finding a well-built custom home with space and quality, this house checks a lot of boxes. This brick home built in 2020 has 4-bedrooms, 3-bathrooms with 2,523 square feet on nearly an acre lot. It also offers an open & split floor plan, formal dining room, quartz countertops, luxury vinyl floors, crown molding, and a Thor gas range. The master suite has a soaking tub, walk-in shower, and oversized closet. Two fireplaces including one outside, spray foam insulation, two water heaters, generator hookup, walk-up stairs to the huge attic, bonus storage room, and a two-car garage. This is an amazing house that is waiting for you to make it your new home!

49 Lancair Drive, Picayune

Listing courtesy of Coldwell Banker Alfonso Realty - DH.

$180,000

3 Beds ⋅ 2 Baths ⋅ 4141077 MLS

If you're interested in quaint country living, this is the one for you! Charming 3-Bedroom, 2-Bathroom Home on .75-Acre Lot with Detached Living Quarters that has so much potential! It has 2 nice sheds as an extra bonus. For someone that can add some TLC, this is the perfect home and priced right! This inviting single-family residence, built in 1978, offers comfortable living with a functional layout and plenty of outdoor space. Situated on a generous .75-acre lot, the property combines privacy, outdoor potential, and room for expansion- perfect for someone wanting animals!

55 Koch Road, Picayune

Listing courtesy of eAgent Gulf Coast (POF).

$990,000

6 Beds ⋅ 5 Baths ⋅ 4140418 MLS

Two stunning residences situated on 7.28 acres have just been newly listed -- offering a rare opportunity for multiple family living or investment potential. With two separate homes on adjoining acreage, this property is ideal for Mother in Law home, extended family, guest quarters, or rental income. Homes are 350 feet apart. Beginning with 11080, this residence features a butler-style kitchen with a large center island, spacious living room, craft room, upstairs bonus room, and generously sized bedrooms. Nestled on 3.5 acres, the property also includes two shops, providing ample storage or workspace. Alternatively, 11804 is a beautiful brick home situated on 3.78 acres, offering three bedrooms, three bathrooms, a sunroom, office, den, and covered back patio. In addition, there is a shop with a full bath and double insulation -- perfect for hobbies, projects, or additional workspace. These properties are truly must-see. An additional 8 acres are also available for purchase if desired.

11084 Road 231 & 11080 Road 231, Picayune

Listing courtesy of RE/MAX Premier Group.

$410,000

4 Beds ⋅ 3 Baths ⋅ 4139309 MLS

105 Jefferson Davis Parkway, Picayune

Listing courtesy of The Smith Team Realty Group DBA The Smith Group Realty.

$336,000

3 Beds ⋅ 3 Baths ⋅ 4130941 MLS

Very secluded and private! This home is hidden away from the main road and is accessible by an easement. There is a large living room with a woodburning fireplace, dining room and kitchen/breakfast area. The kitchen has a walk-in pantry. The laundry room is off the kitchen as well as a .5 bath. The home has a split floor plan. There is ample storage with a storage area/room within the 2-car garage. The interior has just been painted, and all carpet has been replaced. This home has an additional 19.28 acres available that is mostly pasture.

131 Monk Mitchell Road, Picayune

Listing courtesy of Ford Realty, Inc..

$339,000

3 Beds ⋅ 3 Baths ⋅ 4130757 MLS

Discover the PERFECT blend of COMFORT and CONVENIENCE in this BEAUTIFUL 3 Bed/ 2.5 Bath home nestled on one PEACEFUL Acre. This NEWLY listed residence offers an inviting Atmosphere that's ideal for both relaxation and entertainment. Step inside to find a SPACIOUS and Sunlit interior, where each room seamlessly flows into the next. The House features a MODERN Kitchen equipped with all the essentials, perfect for whipping up gourmet meals or a midnight snack. The living area beckons with its cozy ambiance. The primary bedroom is STUNNING with large en-suite, and has a GORGEOUS DECK to enjoy the evening sunsets, additional bedrooms provide plenty of space. Outside has a BEAUTIFUL patio for your ENJOYMENT. Come Take a LOOK at this BEAUTY.

446 Liberty Road, Picayune

Listing courtesy of Templet Realty, LLC.

$325,000

1 Baths ⋅ 4130126 MLS

This is a turnkey Business! Established auto repair business located on busy Hwy. Property is fenced/gated. Survey on file with 1.82 acres. There are 7 ea. 12x14 bay doors, office area, .5 bath and 2 open areas that are covered on a slab. Some tools and equipment will remain. Inventory list of items to purchase will be available to view upon request.

1747 S Hwy. 11, Picayune

Listing courtesy of Ford Realty, Inc..

$234,900

3 Beds ⋅ 2 Baths ⋅ 4127471 MLS

Welcome to 1003 Union School Road, where timeless charm meets modern comfort in the desirable Ponderosa subdivision of Picayune. This beautifully updated 3-bedroom, 2-bath home has been lovingly maintained inside and out, offering the perfect blend of style, functionality, and everyday living. Step inside to discover bright, inviting living spaces and a spacious kitchen designed for gathering with family and friends. Whether you're preparing weeknight dinners or hosting holiday celebrations, you'll love the generous workspace and welcoming layout. Every room reflects pride of ownership, making this home truly move-in ready. Outside, your private backyard retreat awaits. The expansive deck creates the perfect setting for morning coffee, weekend barbecues, or simply relaxing while enjoying the peaceful surroundings. With plenty of room for entertaining and outdoor activities, this backyard is an extension of the home's warm and inviting atmosphere. Beyond the property, you'll enjoy everything that makes Picayune such a wonderful place to call home. Explore charming locally owned shops and restaurants in historic downtown, spend weekends enjoying parks and recreational facilities, or visit the beautiful Crosby Arboretum, one of the region's premier outdoor attractions. Nearby parks like Friendship Park offer playgrounds, walking paths, and community events, while convenient access to Highland Community Hospital, the Stennis Space Center, and Interstate 59 makes commuting to the Mississippi Gulf Coast, Hattiesburg, or New Orleans simple. Ongoing economic growth continues to make the area an attractive place to live and invest. If you've been searching for a home that combines thoughtful updates, exceptional care, and a location that offers both convenience and a true sense of community, this is one you won't want to miss. Schedule your private showing today!

1003 Union School Road, Picayune

Listing courtesy of Century 21 J. Carter & Company.

$547,000

3 Beds ⋅ 3 Baths ⋅ 4127029 MLS

Private and exclusive Master Gardener's country estate for sale for the 1st time. With no neighbors in sight of house, pool, or pond, this home is ideal for those seeking solitude! 8.5 acres of indigenous landscaping will delight year-round. The house is a comfortable custom build and features the primary suite on the main level, as well as an eat-in kitchen, dining room, living room with wood burning fireplace and huge picture windows with views on all sides. The house is wrapped with decks and porches including a screened porch overlooking the pool. The second level features 2 bedrooms with large closets, & views of ponds, a hall bathroom, and a loft office/exercise area with a balcony overlooking the pool. The 2-car garage offers plenty of additional storage + a bathroom with shower. There is also a greenhouse and a sewing/craft room. Stocked pond features a gazebo with electricity, a waterfall, and walking trail around the perimeter. NO HOA FEES. The location cannot be beat! 2nd Picayune exit, past Walmart, Home Depot, Tractor Supply and the boutique subdivision of Plantation Oaks will be on your right, 4 miles from I-59. This estate is at the back of the subdivision, at the end of the Cul de sac. One hour from New Orleans, LA and 30 minutes to the MS Gulf Coast beaches.

22 Nottoway Drive, Picayune

Listing courtesy of Compass.

$619,900

3 Beds ⋅ 4 Baths ⋅ 4125177 MLS

Incredible opportunity with this 6,755 sq. ft. commercial property on approximately 2.34 acres. Recently expanded to include an additional 1.02-acre parcel, this unique property now spans from Highway 43 South to Ceasar Road, offering dual road frontage, excellent accessibility, and outstanding visibility. Located just 5 minutes south of I-59 in Picayune, Hwy 43 sees over 8,900 vehicles daily, while Ceasar Road adds an estimated 4,700 vehicles per day. The versatile layout is ideal for an event venue, restaurant, or mixed-use investment, with rear quarters perfect for Airbnb or guest lodging. The added acreage also creates potential for residential development or additional income opportunities. Now offered at an improved price of $619,900, this rare property delivers size, location, and flexibility with endless possibilities.

2467 S Highway 43 S, Picayune

Listing courtesy of The Real Estate Co., LLC..

$425,000

4 Beds ⋅ 5 Baths ⋅ 4124189 MLS

Now Priced to Sell - Private Cypress Home on 2.51 Acres! Now offered at a new, improved price—don't miss this opportunity to own Parcel #2 on the attached survey, featuring a one-of-a-kind 4-bedroom, 5-bath cypress home situated on 2.51 partially wooded acres. Enjoy the perfect blend of privacy, space, and convenience, all just 15 minutes from the interstate. Step inside to soaring ceilings, abundant natural light, and an updated kitchen with new appliances. Recent improvements—including a brand-new freight elevator, new downstairs A/C unit, and a durable metal roof—provide long-term value and peace of mind. Relax on the spacious Acadian-style front porch or entertain family and friends beneath the expansive covered area below the home, perfect for crawfish boils, barbecues, and outdoor gatherings. The surrounding property offers plenty of room for recreation, gardening, or simply enjoying the peaceful country setting. No Restrictions - Endless Possibilities Bring your animals, add additional buildings, or create the country lifestyle you've always wanted without restrictive covenants. With its new lower price, valuable updates, and added incentives, this property delivers outstanding value. Don't miss your opportunity to own this unique country retreat—schedule your private showing today!

7711 Cuevas Town Road, Picayune

Listing courtesy of Allied Realty Coastal Homes.

$339,000

6 Beds ⋅ 4 Baths ⋅ 4116440 MLS

Spanning 12.7 acres, this property provides ample space for both relaxation and entertainment. This versatile home offers 6 bedrooms, 3.5 bathrooms, 2 full kitchens and 2 living areas, giving you the flexibility to enjoy it as one large home or divided into separate living spaces. The additional area is perfect as a guest suite or private apartment. Ideal for hosting or rental income. Outside you will find a large metal workshop for utility and storage. Despite its peaceful, rural atmosphere, the home is conveniently located close to town and Interstate 59, ensuring easy access to urban amenities and travel routes. Whether you're seeking a quiet retreat or a vibrant space to entertain, this property offers the best of both worlds.

38 Eldridge Patch Road, Picayune

Listing courtesy of Berkshire Hathaway Home Servs., Panoramic Properties.

$995,000

4102259 MLS

High visibility commercial property fronting I59 South exit 4 ramp. Access to property is from S. Loftin Street off of Memorial Blvd.

00 I59 South Exit 4, Picayune

Listing courtesy of Ford Realty, Inc..

$219,000

3377719 MLS

This is Tract #7. Great location with high visibility. Located just north of Highland Hospital with restaurants and shopping in immediate area.

11 Highway, Picayune

Listing courtesy of Ford Realty, Inc..

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Copyright 2026 Mississippi Gulf Coast Multiple Listing Service, Inc. Buyer and/or Buyer's Agent should verify data and evaluate source. This information is furnished by the Mississippi Gulf Coast Multiple Listing Service, Inc. This data is copyrighted and may not be transmitted, retransmitted, copied, framed, repurposed, or altered in any way for any other site, individual and/or purpose without the express written permission of the Mississippi Gulf Coast Multiple Listing Service, Inc. All properties are subject to prior sale, change or withdrawal. Neither the MLS nor the Listing Broker will be held responsible for any typographical errors, misinformation and misprints and shall be held totally harmless. Data displayed is a portion of, and not a complete listing of all listing information published in the Mississippi Gulf Coast Multiple Listing Service, Inc.

2250+ Sq. Ft. Picayune Real Estate

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